NFL Weekly Preview Week 15 2025: Key Injuries, Difference Makers & Projected Upsets

Lamar Jackson (Darron Cummings, Google Images)

We begin the 15th week of the 2025 NFL regular season on Thursday. Here are the key injuries, fantasy stars and projected upsets. Congratulations to all who made their fantasy football playoffs!

Key Injuries

Washington Commanders quarterback Jayden Daniels (elbow) will not play this week. Players out for the season include Cincinnati Bengals defensive end Trey Hendrickson (core muscle surgery), cornerback Kyu Blu Kelly (patellar tendon tear), Indianapolis Colts quarterback Daniel Jones (torn Achilles), and Washington Commanders tight end Zach Ertz (torn anterior cruciate ligament). The Jones injury led the Colts to signing 44-year-old Philip Rivers this past week.

Fantasy Stars

The top rated quarterback is Lamar Jackson of Pompano Beach, Florida. He is projected to get 226 passing yards, 36 rushing yards and two touchdowns against the Cincinnati Bengals. The Ravens will be looking for redemption as the Bengals beat the Ravens 32-14 on American Thanksgiving Day night. The top rated wide receiver is Puka Nacua of the Los Angeles Rams. The native of Las Vegas, Nevada is projected to get eight catches for 109 receiving yards and one touchdown on Sunday against the Detroit Lions. The top rated running back is Jahmyr Gibbs of the Detroit Lions. Despite having a tough matchup against the Los Angeles Rams, the native of Dalton, Georgia is projected to get 108 total yards (76 rushing yards and 32 receiving yards) and one touchdown.

Projected Upsets

I like one underdog this week. It is Detroit to beat the Los Angeles Rams. Expect a high scoring contest in this one, as both offenses are among the top four in the NFL.