2025 NFL Week 10 Preview: Our Expert Tips

The NFL season is heating up, and we’re here once again with our weekly betting breakdowns to help you find an edge. From injury updates to roster shake-ups and early ATS trends, we’ve got you covered with insights on the biggest matchups of the week. Let’s dive into our latest previews and see where the value lies.

I will likely be adding some more picks before the games, so make sure to check back.

Atlanta Falcons @ Indianapolis Colts

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Indianapolis hosts the Falcons as a strong favorite, and the edge leans toward the Colts covering the spread. The Colts remain relatively healthy on offense and bring a dynamic attack complemented by a rushing game that controls tempo. Yet they face a hurdle on defense: DT DeForest Buckner has been placed on Injured Reserve with a neck injury, and DEs Samson Ebukam and Tyquan Lewis are ruled out, leaving the interior line vulnerable and possibly inviting more running plays from the Falcons.

The Falcons, meanwhile, are battling their own slew of injuries. Starting guard Matthew Bergeron is out with an ankle injury, swing tackle Storm Norton is sidelined with a foot issue, and star edge rush Leonard Floyd remains unavailable with a hamstring injury. That depth erosion upfront hampers Atlanta’s ability to protect and generate pressure.

ATS trends favor teams like the Colts: healthy road favorites in division-matchup spots where their opponent’s offensive line is weakened cover at a higher clip than typical double-digit favorites. With Atlanta’s protection issues plus Indianapolis’ offensive efficiency, the spread looks achievable for the home side.

Pick: Colts −6.5

USA USER BETS

• 2 units ($200) Colts -6.5 @ -110 Bet With BetUS Here

AUS/ UK USER BETS

• 2 units ($200) Colts -6.5 @ 1.89 Bet With Unibet Here

New York Giants @ Chicago Bears

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New York travels to Chicago as moderate underdogs, but this spot offers value for backing the Giants to cover—and potentially win outright. The Bears carry several notable injuries: linebacker T.J. Edwards is out after hand surgery and continues to deal with a hamstring issue; cornerback Josh Blackwell is out with a concussion; and defensive end Dominique Robinson is sidelined with an ankle injury. Running back D’Andre Swift is questionable with a groin injury and missed Friday’s practice for personal reasons—casting doubt on Chicago’s offensive power.

The Giants’ injury list is longer but less impactful in matching roles for this game: cornerback Paulson Adebo is out (knee), right tackle Jermaine Eluemunor is questionable (pectoral), and kicker Graham Gano is sidelined with a neck injury, with Younghoe Koo expected to step in. New York’s offense has shown resilience, and their defense has created pressure despite thin depth.

From a trends perspective, road underdogs in the +4 to +5 range produce strong ATS returns when the home team is dealing with front-seven or secondary injuries. With Chicago’s protection and defensive issues mounting and New York entering with nothing to lose, the Giants are well-positioned to stay within the number.

Pick: Giants +4.5

USA USER BETS

• 2 units ($200) Giants +4.5 @ -110 Bet With BetUS Here
• 1 units ($100) Giants moneyline @ +183 Bet With BetUS Here

AUS/ UK USER BETS

• 2 units ($200) Giants +4.5 @ 1.92 Bet With Unibet Here
• 1 units ($100) Giants moneyline @ 2.85 Bet With Unibet Here

New England Patriots @ Tampa Bay Buccaneers

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The Patriots head into Tampa as underdogs with a spread of +2.5, but there’s clear value on New England covering—and possibly pulling the outright win. The Buccaneers are missing several key contributors: WR Chris Godwin is out with a fibula injury, RB Bucky Irving remains sidelined (foot/shoulder), and OLB Haason Reddick is ruled out with ankle/knee issues. Meanwhile, the Patriots have their own absences—RB Rhamondre Stevenson, WR Kayshon Boutte, and LB Christian Elliss are all ruled out—but these holes might be less impactful given their offensive balance and depth.

New England has won six straight and is 4-0 on the road this season, showing resilience away from home. From a betting-trend perspective, underdogs of +2 to +3 who are on the road and facing a favorite with key offensive absences cover more often than expected. Given Tampa Bay’s weakened skill-position group and the Patriots’ momentum, New England has the structure to stay within the number—or upset.

Pick: Patriots +2.5

USA USER BETS

• 2 units ($200) Patriots +2.5 @ Ev Bet With BetUS Here
• 1 units ($100) Patriots moneyline @ +150 Bet With BetUS Here

AUS/ UK USER BETS

• 2 units ($200) Patriots +2.5 @ 1.90 Bet With Unibet Here
• 1 units ($100) Patriots moneyline @ 2.05 Bet With Unibet Here

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Arizona Cardinals @ Seattle Seahawks

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Arizona heads to Seattle not as favorites but with value on the +6.5 spread, and possibly more. The Cardinals are heading into the matchup with quarterback Kyler Murray on injured reserve, so Jacoby Brissett is set to start. While Murray’s absence is notable, the Cardinals’ defense enters the game in strong form—they’ve held opponents under 20 points in multiple recent outings and will face a Seahawks team missing key players. Seattle’s injury list includes defensive tackle Jarran Reed (wrist/thumb, ruled out), cornerback Josh Jobe (concussion, out), and inside linebacker Ernest Jones IV (knee, doubtful). Each of those absences weakens the Seahawks’ ability to stop running backs and protect the inner lane.

For Arizona, right guard Will Hernandez is questionable with a knee injury, but the greater concern is on the Seahawks side. With their back-up signal-caller and missing defensive disruptors, Seattle may struggle to control tempo and protect against a purposeful Cardinals offense. Betting trends indicate that road underdogs of 5-7 points often cover when the home team is managing multiple defensive starters out or questionable. The Cardinals’ maturity, combined with Seattle’s defensive vulnerabilities, gives Arizona a strong chance to stay within the number—or even sneak away with an upset.

Pick: Cardinals +6.5

USA USER BETS

• 2 units ($200) Cardinals +7 @ -115 Bet With BetUS Here
• 1 units ($100) Cardinals moneyline @ +275 Bet With BetUS Here

AUS/ UK USER BETS

• 2 units ($200) Cardinals +6.5 @ 1.94 Bet With Unibet Here
• 1 units ($100) Cardinals moneyline @ 3.65 Bet With Unibet Here

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Detroit Lions @ Washington Commanders

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Detroit hits the road favored by 8.5 points, and this line has value based on Washington’s current roster fractures. The Commanders just lost QB Jayden Daniels to a dislocated elbow and now turn to veteran Marcus Mariota as the starter—an unideal situation for a squad already in freefall. On top of that, WR Terry McLaurin is also ruled out, severely limiting their receiving arsenal.

The Lions aren’t injury-free either — S Kerby Joseph and RB Jacob Saylors are out this week — but they haven’t lost their identity on offense. Detroit is still methodical with the run-pass mix and continues to get chunk plays from its weapons. With Washington’s offense transitioning and missing key playmakers, the matchup tilts heavily to a Lions attack that can short-handoff against a tired defense and force Mariota into mistakes.

ATS trends support strong favorites covering when the opponent loses its starting quarterback and a top wideout in the same week. Detroit’s depth advantage, offensive efficiency, and Washington’s diminished state create an ideal setup to not just win but cover emphatically at Arrowhead.

Pick: Lions −8

USA USER BETS

• 2 units ($200) Lions -8 @ -110 Bet With BetUS Here

AUS/ UK USER BETS

• 2 unit ($200) Lions -8 @ 1.91 Bet With Unibet Here

Enter Our $500 Cash Giveaway Here

Expert Tips

• 2 units ($200) Colts -6.5 @ 1.89 Bet With Unibet Here
• 2 units ($200) Giants +4.5 @ 1.92 Bet With Unibet Here
• 1 units ($100) Giants moneyline @ 2.85 Bet With Unibet Here
• 2 units ($200) Patriots +2.5 @ 1.90 Bet With Unibet Here
• 1 units ($100) Patriots moneyline @ 2.05 Bet With Unibet Here
• 2 units ($200) Cardinals +6.5 @ 1.94 Bet With Unibet Here
• 1 units ($100) Cardinals moneyline @ 3.65 Bet With Unibet Here
• 2 unit ($200) Lions -8 @ 1.91 Bet With Unibet Here