2025 NFL Week 6 Preview: Our Expert Tips & Staking Plan

We are back! The new NFL season is underway and we are back with our expert tips that have hopefully served you well in the past.

I will likely be adding some more picks before the games so make sure to check back.

Seattle Seahawks @ Jacksonville Jaguars

Seattle travels to Jacksonville as a slight road favorite, and despite a vulnerable secondary, the Seahawks look poised to win outright. Their defense is thin: Devon Witherspoon, Julian Love, and Riq Woolen are all listed as doubtful or out with injuries, weakening Seattle’s coverage in the back. Seattle’s offense, however, has shown flashes—particularly through Sam Darnold and Jaxon Smith-Njigba, who’ve connected on multiple big plays so far. Tight end A.J. Barner has also become a red-zone factor, recently posting multiple touchdowns in a game, which adds another vertical threat.

Jacksonville, meanwhile, lost TE Brenton Strange to IR, significantly weakening their tight end production and blocking in-line. Center Robert Hainsey is doubtful, so rookie Jonah Monheim may see more snaps—and that could create protection problems against Seattle’s defensive front. Defensive end Travon Walker is back and expected to play, which helps their rush scheme, but Seattle’s front remains dangerous and disciplined.

Trendwise, small spreads of ±1 point often lean toward the more consistent roster—especially when road teams are favored. If Seattle can stay out of the secondary mess and win with offense and pressure, they have a good shot to pull off the outright.

Pick: Seahawks −1 (ML lean)

USA USER BETS

• 2 units ($200) Seahawks Moneyline @ -110 Bet With BetUS Here

AUS/ UK USER BETS

• 2 units ($200) Seahawks Moneyline @ 1.86 Bet With Unibet Here

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Cleveland Browns @ Pittsburgh Steelers

The Browns head into Pittsburgh as 6-point underdogs, but there’s value in backing Cleveland to keep this in reach—or even steal one. Dante out: DT Mike Hall Jr. is officially ruled out this week, weakening depth on Cleveland’s defensive front. But the Browns’ edge defenders—Myles Garrett, Mason Graham, and Maliek Collins—still form a disruptive unit capable of collapsing pockets and applying consistent pressure.

On offense, Dillon Gabriel remains steady after a promising showing last week, and the Browns have elevated rookie Shedeur Sanders to backup following the Joe Flacco trade. That move further commits the franchise to a youthful signal-caller rollout. Pittsburgh, for its part, has gotten healthier: Jalen Ramsey is expected back after hamstring rest, and Joey Porter Jr. returns from injury. However, the Steelers will still be missing WR Calvin Austin III, trimming depth in their passing game.

Historically, double-digit home favorites see a measurable ATS fade when facing motivated underdogs with physical defenses. The Browns’ defensive identity and willingness to mix in pressure schemes give them a path to force stops and stay in this. If Gabriel holds off turnovers and the Browns’ front can dictate gaps, don’t be shocked if this game stays within one score.

Pick: Browns +6

USA USER BETS

• 2 units ($200) Browns +6 @ -110 Bet With BetUS Here
• 2 units ($200) Browns moneyline @ +230 Bet With BetUS Here

AUS/ UK USER BETS

• 2 units ($200) Browns +6 @ 1.90 Bet With Unibet Here
• 1 unit ($100) Browns moneyline @ 3.30 Bet With Unibet Here

Enter Our $500 Cash Giveaway Here

New England Patriots @ New Orleans Saints

New England hits the road in New Orleans as a modest favorite, and they’re carrying real momentum after a gritty win last week. The Saints are thin across several positions: Isaac Yiadom is officially out, Alvin Kamara and John Ridgeway III are questionable, and their depth at cornerback is shaky. Meanwhile, Chase Young may debut off injury, which could shake matchups along the edge.

The Patriots, though battered, are showing resilience. Four players are ruled out: Antonio Gibson, Keion White, Anfernee Jennings, and Jaylinn Hawkins. Key others — Christian Gonzalez, Marte Mapu, and Charles Woods — are all questionable heading into the matchup. Losing Gibson to a season-ending injury is a blow, leaving Rhamondre Stevenson and TreVeyon Henderson to carry the load in the backfield. New defensive play-caller Zak Kuhr continues to call the defense in place of Terrell Williams.

Trends suggest that road favorites of 3 to 4 points often outperform expectations when the underdog is managing injuries. With New England’s resilient secondary and a veteran-driven offensive approach, they have the structure to stay in this and strike late. If the Saints’ backups falter in coverage or protection breaks down, the Pats could edge it.

Pick: Patriots −3.5

USA USER BETS

• 2 units ($200) Patriots -3.5 @ -105 Bet With BetUS Here

AUS/ UK USER BETS

• 2 unit ($200) Patriots -3.5 @ 1.96 Bet With Unibet Here

Enter Our $500 Cash Giveaway Here

Denver Broncos @ New York Jets (In London)

This London tilt offers a rare neutral-site feel, and Denver enters with a clear edge despite losing left guard Ben Powers to IR, having had surgery for a torn biceps. His absence weakens their interior protection and run-blocking cohesion, especially across the pond. Also ruled out is OLB Jonah Elliss, leaving depth gaps that the Jets might try to exploit. But the Broncos still bring advantages in roster continuity, rushing attack, and defensive front play.

The Jets are reeling at 0–5 and have their own health issues. Michael Carter II is out with a concussion, Allen Lazard is unavailable for personal reasons, and cornerback Brandon Stephens is dealing with a neck ailment that makes his availability questionable. While edge rusher Jermaine Johnson II is active again, the Jets’ overall defense has been porous, especially against the run.

From a trend perspective, heavy spreads in international games tend to regress toward smaller margins because home-field advantage is diluted. But Denver’s physical identity, bolstered run game, and overall roster depth suggest they can impose their style. If they protect the pocket and win the trenches, they should cover.

Pick: Broncos −6.5

USA USER BETS

• 2 units ($200) Broncos -7 @ -110 Bet With BetUS Here

AUS/ UK USER BETS

• 2 unit ($200) Broncos -6.5 @ 1.85 Bet With Unibet Here

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Detroit Lions @ Kansas City Chiefs

The Chiefs welcome Detroit to Arrowhead as modest favorites in this Sunday Night showdown, and all signs point to KC covering. Kansas City returns to relative health, with no major injury designations reported for key starters. The offense remains anchored by Patrick Mahomes, who continues to generate explosive plays even under duress—and with Xavier Worthy now questionable due to a lingering ankle issue, the Chiefs’ offense may tilt toward increased run and intermediate routes.

Detroit, meanwhile, is dealing with a challenging injury wave. Four players are already ruled out, including running back Vaki, linebacker Cunningham, and DT McNeill. On top of that, six others—among them Decker, Branch, Joseph, and Maddox—are listed as game-time decisions, raising doubts about their defensive backfield availability. That could open up matchups for Kansas City’s receivers in crucial third-down and end-zone situations.

From a betting lens, small spreads — especially under 3 points — in primetime games lean toward the more dynamic roster, and Kansas City fits the bill. Their edge in playmaking, healthier offensive line, and home-field crowd noise put them in a strong position to both win and cover.

Pick: Chiefs −2.5

USA USER BETS

• 2 units ($200) Chiefs -1.5 @ -120 Bet With BetUS Here

AUS/ UK USER BETS

• 2 unit ($200) Chiefs -2.5 @ 1.93 Bet With Unibet Here

Enter Our $500 Cash Giveaway Here

Expert Tips

• 2 units ($200) Seahawks Moneyline @ 1.86 Bet With Unibet Here
• 2 units ($200) Browns +6 @ 1.90 Bet With Unibet Here
• 1 unit ($100) Browns moneyline @ 3.30 Bet With Unibet Here
• 2 unit ($200) Patriots -3.5 @ 1.96 Bet With Unibet Here
• 2 unit ($200) Broncos -6.5 @ 1.85 Bet With Unibet Here
• 2 unit ($200) Chiefs -2.5 @ 1.93 Bet With Unibet Here