2025 NFL Week 5 Preview: Our Expert Tips

Kansas City Chiefs quarterback Patrick Mahomes runs onto the field during team introductions prior to an NFL Divisional Playoff football game against the Jacksonville Jaguars Saturday, Jan. 21, 2023, in Kansas City, Mo. (AP Photo/Ed Zurga)

The NFL season is heating up, and we’re here once again with our weekly betting breakdowns to help you find an edge. From injury updates to roster shake-ups and early ATS trends, we’ve got you covered with insights on the biggest matchups of the week. Let’s dive into our latest previews and see where the value lies.

I will likely be adding some more picks before the games, so make sure to check back.

Dallas Cowboys @ New York Jets

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Dallas rides into MetLife as slight favorites, but the edge leans toward the Jets to cover—and possibly win outright. The Cowboys continue to pile up injuries on offense: left tackle Tyler Guyton (concussion) is out, safety Malik Hooker has been placed on IR, and wideout CeeDee Lamb (ankle) is questionable. Their protection and receiving corps could be compromised, giving New York a shot to disrupt rhythm.

The Jets aren’t unscathed either: RB Braelon Allen is sidelined long term with an MCL injury, putting more load on Breece Hall and Isaiah Davis. Guard Alijah Vera-Tucker is out for the season after a torn triceps, weakening their line. Yet they benefit from home-field and a motivated crowd in a must-win situation under new coach Aaron Glenn.

Trend-wise, home underdogs at narrow spreads often come in higher than expected, especially when the favorite is dealing with key absences. If the Jets can get pressure on Prescott and control the line of scrimmage early, they have a path to pull off an upset.

Pick: Jets +1.5 (ML upside)

USA USER BETS

• 2 units ($200) Jets +1 @ -105 Bet With BetUS Here

AUS/ UK USER BETS

• • 2 units ($200) Jets +1.5 @ 1.91 Bet With Unibet Here

Cleveland Browns @ Minnesota Vikings (In London)

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The Browns head to London as modest underdogs, trading expected respect for a line that makes value lean their way. Cleveland has officially named rookie Dillon Gabriel their starter—benching Joe Flacco after four games of turnover struggles. Gabriel’s mobility and timing will be tested in this international debut under center.

Minnesota enters dealing with losses as well—key offensive-line pieces like RT Brian O’Neill (knee) and LG Donovan Jackson (wrist) are out, creating potential mismatches against a Browns defensive front that remains among the league’s strongest against the run. That could force Minnesota into more passing downs than preferred.

Cleveland has leaned into disguising pressure and mixing zone coverages to complicate reads for QBs and with Carson Wentz showing in the past that he can mae mistakes when under pressure, expect some turnovers.

Gabriel’s success may hinge on quick reads, bootlegs, and timing throws to speedier receivers. Given the neutral/foreign-site setting, home-field advantage is lessened — and ATS data shows that underdogs in the 3–4 point range can cover at elevated rates in these matchups. With Minnesota’s O-line holes and Cleveland’s strength in defensive disruption, the Browns are in position not just to cover but to steal a win.

Pick: Browns +3.5 (lean ML)

USA USER BETS

• 2 units ($200) Browns +3.5 @ -115 Bet With BetUS Here

AUS/ UK USER BETS

• 2 units ($200) Browns +3.5 @ 1.91 Bet With Unibet Here

Houston Texans @ Baltimore Ravens

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Baltimore enters as a rare home underdog (around a point or two), with Lamar Jackson ruled out and veteran Cooper Rush starting. That lowers the ceiling, but the Ravens can still shape this into a script they like: lean on Derrick Henry behind a physical front, keep Rush in rhythm with Mark Andrews and Zay Flowers on quick-game concepts, and let their defensive line muddy the pocket. Health remains a factor—key defensive starters in the back seven have been sidelined or limited—but the front (Justin Madubuike & Co.) is capable of compressing throwing lanes and forcing Houston into longer drives.

For the Texans, Tank Dell is sidelined, trimming some vertical juice from an otherwise efficient C.J. Stroud attack. If Baltimore can bracket Nico Collins and win early downs, Houston’s offense becomes more methodical and easier to contain. In tight, low-total matchups, short home underdogs historically profile well, especially when they can run the ball and control tempo.

Bottom line: even with a backup QB, the Ravens’ trench edge, home crowd, and red-zone tight-end advantage give them a path to a grind-it-out result—plus the points and potentially the win.

Pick: Ravens +1 (ML sprinkle)

USA USER BETS

• 2 units ($200) Ravens +1 @ -105 Bet With BetUS Here

AUS/ UK USER BETS

• 2 unit ($200) Ravens +1 @ 1.93 Bet With Unibet Here

Enter Our $500 Cash Giveaway Here

Tennessee Titans @ Arizona Cardinals

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Arizona returns home as the favorite in this AFC–NFC clash, but the +7.5 line gives value to Tennessee, especially if they stay competitive deep into the game. The Cardinals are significantly shorthanded in the run game: James Conner is done for the season, and Trey Benson has been placed on IR. That leaves Emari Demercado and Michael Carter as the likely rush options, reducing Arizona’s ground threat.

Meanwhile, Tennessee enters with injuries of its own. JC Latham remains out, weakening the tackle spot. WR Bryce Oliver and S Mike Brown are both ruled out, while Calvin Ridley practices limited and is questionable. On offense, rookie Cam Ward continues under center, still seeking consistent rapport with his receiving corps under pressure. The Titans’ run defense has shown flashes, and with Arizona’s rushing depth compromised, they may press more in the passing game’s intermediate levels.

From an ATS angle, large spreads early in the season often see underdogs play tougher than expected, especially when public perception leans toward the inflated favorite. If Tennessee can protect the pocket and mix in enough runs, they have a shot to keep this within one score. Given Arizona’s weakened rushing options and Tennessee’s resilient mindset, the Titans are in position to grind out the cover—even sniff a win outright.

Pick: Titans +7.5

USA USER BETS

• 2 units ($200) Titans +7.5 @ -110 Bet With BetUS Here

AUS/ UK USER BETS

• 2 unit ($200) Titans +7.5 @ 1.90 Bet With Unibet Here

Enter Our $500 Cash Giveaway Here

Kansas City Chiefs @ Jacksonville Jaguars

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Kansas City hits the road laying 3.5 points, and while Jacksonville has shown flashes of improvement, the matchup leans toward the Chiefs. Patrick Mahomes remains the ultimate equalizer, and he’ll get a boost from WR Xavier Worthy, who returned from a shoulder issue and has added much-needed speed to the passing game. With Travis Kelce healthy and Isiah Pacheco running with power, the Chiefs’ offense is well balanced heading into this one.

Defensively, Kansas City has injury concerns — Mike Danna is doubtful, and depth at edge rusher is thin — but their secondary has held up better than expected. The Jaguars, meanwhile, are banged up along the offensive line: Wyatt Milum is out and Ezra Cleveland is questionable, which could expose Trevor Lawrence to added pressure. Jacksonville’s passing game has leaned on rookie WR Brian Thomas Jr., but with protection compromised, consistency will be a challenge.

From a betting trends standpoint, Kansas City has thrived in this spot. The Chiefs are 9-4 ATS in their last 13 games as road favorites of a field goal or more, and Mahomes rarely drops consecutive road covers. With Jacksonville thin up front, the Chiefs’ talent gap should show.

Pick: Chiefs -3.5

USA USER BETS

• 2 units ($200) Chiefs -3.5 @ -105 Bet With BetUS Here

AUS/ UK USER BETS

• 2 unit ($200) Chiefs -3.5 @ 1.96 Bet With Unibet Here

Enter Our $500 Cash Giveaway Here

Expert Tips

• 2 units ($200) Jets +1.5 @ 1.91 Bet With Unibet Here
• 2 units ($200) Browns +3.5 @ 1.91 Bet With Unibet Here
• 2 unit ($200) Ravens +1 @ 1.93 Bet With Unibet Here
• 2 unit ($200) Titans +7.5 @ 1.90 Bet With Unibet Here
• 2 unit ($200) Chiefs -3.5 @ 1.96 Bet With Unibet Here