2025 NFL Week 4 Preview: Our Expert Tips

Kansas City Chiefs quarterback Patrick Mahomes runs onto the field during team introductions prior to an NFL Divisional Playoff football game against the Jacksonville Jaguars Saturday, Jan. 21, 2023, in Kansas City, Mo. (AP Photo/Ed Zurga)

The NFL season is heating up, and we’re here once again with our weekly betting breakdowns to help you find an edge. From injury updates to roster shake-ups and early ATS trends, we’ve got you covered with insights on the biggest matchups of the week. Let’s dive into our latest previews and see where the value lies.

I will likely be adding some more picks before the games, so make sure to check back.

Minnesota Vikings @ Pittsburgh Steelers (In Ireland)

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The Steelers and Vikings will battle in the first-ever regular-season NFL game in Dublin, a landmark event with global attention. While Pittsburgh leans on Aaron Rodgers under center and vowing a strong showing abroad, the Vikings bring a more balanced and confident roster into this showdown.

Minnesota will be without edge rusher Andrew Van Ginkel (neck) and guard Donovan Jackson (wrist), while quarterback J.J. McCarthy is also out; Carson Wentz steps in under center. Pittsburgh, meanwhile, is without Alex Highsmith (ankle), and DeShon Elliott is managing MCL soreness—he may miss snaps or be limited.

On offense, the Vikings’ running game is humming, notably with new acquisition Jordan Mason making waves; given Pittsburgh’s vulnerability against the run, he’s a strong bet to find the end zone. Defensively, Minnesota’s unit—retooled under Brian Flores—looks capable of disrupting Rodgers and bottling up intermediate routes.

Pick: Vikings −2.5, with Jordan Mason to score a touchdown

USA USER BETS

• 2 units ($200) Vikings -2 @ -120 Bet With BetUS Here

AUS/ UK USER BETS

• 2 units ($200) Vikings -2.5 @ 1.88 Bet With Unibet Here
• 1 unit ($100) Jordan Mason any time TD @ 1.70 Bet With Unibet Here

Cleveland Browns @ Detroit Lions

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Detroit enters this Week 4 showdown laying 10 points at home, but sharp bettors will take notice: Cleveland owns one of the strongest run defenses in the league, allowing just ~45.5 rushing yards per game and a stingy 2.1 yards per carry—both elite marks. That strength is a looming hurdle for Detroit’s backfield tandem of Jahmyr Gibbs and David Montgomery, who may find daylight scarce and defensive fronts squeezing lanes.

Injury-wise, Detroit faces uncertainty in its trenches. Taylor Decker, the Lions’ veteran left tackle, is questionable with a shoulder issue and has missed multiple practices this week. Without him at full strength, Cleveland’s defensive line—hit by Myles Garrett’s disruptive pressure and consistent double teams—could exploit protection breakdowns. On the Browns’ side, the injury report is lighter though Jack Conklin is listed as questionable, and a generally available core gives them depth.

Trend-wise, teams getting double-digit points on the road often outperform the spread when playing a top defense; Cleveland has covered 55%+ of the time in those spots over the past few seasons. With Detroit potentially hampered up front and a punishing Cleveland run defense in front of them, expect the Browns to keep this closer than the public believes.

Pick: Browns +10

USA USER BETS

• 2 units ($200) Browns +10 @ -110 Bet With BetUS Here

AUS/ UK USER BETS

• 2 units ($200) Browns +10 @ 1.90 Bet With Unibet Here

Baltimore Ravens @ Kansas City Chiefs

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The Ravens @ Chiefs matchup presents a rare betting anomaly: Kansas City is a home underdog, a spot the Chiefs seldom occupy. That alone makes backing KC intriguing.

Kansas City gets a boost with WR Xavier Worthy cleared to return from a shoulder injury, restoring a much-needed explosive playmaker in Mahomes’s arsenal. On the injury front, DE Mike Danna is downgraded to doubtful and Ashton Gillotte remains questionable, slightly weakening their pass rush.

Baltimore faces its own lineup setbacks: Pro Bowl DT Nnamdi Madubuike is ruled out with a neck injury, and additional gaps at Ronnie Stanley (ankle) and Isaiah Likely (foot) are looming questions.

From a trends perspective, road favorites in this kind of tight spread—and especially in uncommon home-underdog settings—often surprise. The Chiefs are 8–3–1 ATS as underdogs in Mahomes’s starts, and given how irregular it is for KC to be underdog at Arrowhead, catching this line at +2.5 has value.

USA USER BETS

• 2 units ($200) Chiefs +2.5 @ Ev Bet With BetUS Here
• 1 units ($100) Chiefs Moneyline @ +125 Bet With BetUS Here

AUS/ UK USER BETS

• 2 unit ($200) Chiefs @ 1.95 Bet With Unibet Here
• 1 unit ($100) Chiefs Moneyline @ 2.23 Bet With Unibet Here

Enter Our $500 Cash Giveaway Here

Chicago Bears @ Las Vegas Raiders

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The Raiders host the Bears this week in what appears to be a trap game—Las Vegas is favored, but Chicago has value to win outright. The Silver & Black are short on crucial tight end depth: Michael Mayer remains in concussion protocol and is ruled out, forcing Brock Bowers to carry the TE workload. Their offense also continues to suffer from poor line play and protection breakdowns, giving Geno Smith more pressure than he can afford. Meanwhile, receiver Jakobi Meyers has reportedly requested a trade, a distraction that may sap focus midweek.

On the Bears’ side, injuries are mounting: right tackle Darnell Wright and defensive tackle Grady Jarrett are ruled out, while linebacker T.J. Edwards (hamstring) is also out. The secondary is brittle, too, with cornerback Jaylon Johnson now on IR. Still, QB Caleb Williams is gaining chemistry with his weapons—Rome Odunze, DJ Moore, and Luther Burden—a trio capable of exploiting holes in the Raiders’ secondary.

Against-the-spread trends also support an underdog bet here: road teams under public pressure with offensive momentum have upset home favorites at rates higher than expected early in the season. Given the Raiders’ distractions and Chicago’s ascending offense, betting on the Bears to pull off a win isn’t reckless—it’s opportunistic.

Pick: Bears ML

USA USER BETS

• 2 units ($200) Bears moneyline @ Ev Bet With BetUS Here

AUS/ UK USER BETS

• 2 unit ($200) Bears moneyline @ 1.94 Bet With Unibet Here

Enter Our $500 Cash Giveaway Here

Cincinnati Bengals @ Denver Broncos

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The Bengals head to Denver as underdogs, but +7.5 is an attractive line given recent roster turbulence. Cincinnati will be without Noah Fant, who remains in concussion protocol, and edge prospect Shemar Stewart is also out. Their offense will be led by Jake Browning, as Joe Burrow continues recovering from turf-toe surgery. That likely shifts the Bengals towards a more controlled, shorter passing game with less risk vertically.

Denver’s defense takes a hit, too. Veteran linebacker Dre Greenlaw has been placed on short-term IR with a thigh injury, removing a key run-stopping and coverage piece from their front seven. Meanwhile, the Broncos are hopeful that Evan Engram returns to full practice status, which could open up mismatches in the passing game.

From a trends perspective, road underdogs in the 5–10 point window often outperform expectations, especially when public leans heavily toward the home side. With Denver’s defense now thinner and Cincinnati still carrying dangerous weapons like Tee Higgins and Ja’Marr Chase, the Bengals have the pieces to stay within a score or pull a mild upset.

Pick: Bengals +7.5

USA USER BETS

• 2 units ($200) Bengals +7.5 @ -115 Bet With BetUS Here

AUS/ UK USER BETS

• 2 unit ($200) Bengals +7.5 @ 1.90 Bet With Unibet Here

Enter Our $500 Cash Giveaway Here

Expert Tips

• 2 units ($200) Vikings -2.5 @ 1.88 Bet With Unibet Here
• 1 unit ($100) Jordan Mason any time TD @ 1.70 Bet With Unibet Here
• 2 units ($200) Browns +10 @ 1.90 Bet With Unibet Here
• 2 unit ($200) Chiefs @ 1.95 Bet With Unibet Here
• 1 unit ($100) Chiefs Moneyline @ 2.23 Bet With Unibet Here
• 2 unit ($200) Bears moneyline @ 1.94 Bet With Unibet Here
• 2 unit ($200) Bengals +7.5 @ 1.90 Bet With Unibet Here