NFL Weekly Preview Week 3 2025: Key Injuries, Difference Makers & Projected Upsets
September 19, 2025

We begin the second week of the 2025 NFL regular season on Thursday. Here are the key injuries, fantasy stars and projected upsets.
Key Injuries
We documented the serious injuries to Joe Burrow, JJ McCarthy and Aaron Jones in our week two recap. We also can confirm Austin Ekeler did indeed tear his Achilles in Washington’s loss to Green Bay last Thursday. He will be gone for the season. Also in the Thursday nighter, Packers wide receiver Jayden Reed broke his collarbone and is out two months. Meanwhile, Justin Fields will not quarterback the New York Jets on Sunday against the Tampa Bay Buccaneers because of a concussion. Other notable injuries include Dallas Cowboys center Cooper Beebe (six to eight weeks with a high ankle sprain), and Chicago Bears cornerback Jaylon Johnson (out for the season with a groin injury).
Projected Upsets
I like five underdogs this week. They are the Carolina Panthers, Houston Texans, Cincinnati Bengals, Denver Broncos and the Arizona Cardinals.
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